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Swedish scientists have proven that, by lowering the level of apolipoprotein C3, it is possible to treat the metabolic disorder, resulting from eating foods rich in fat.
And Science Advances notes that eating fatty foods regularly increases the risk of obesity, type 2 diabetes, cardiovascular disease and liver disease.
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It is reported that the scientists of the Rolf Luft Research Center at the Swedish Karolinska Institute, discovered earlier, that the high level of APO C3 (apo C-3) is related to cardiovascular disease and type 2 diabetes, as this is the main regulator of the metabolism process. Dietary fat accumulates in the insulin-producing part of the pancreas (Langerhans Islands), causing increased insulin resistance.
In the new study, the researchers demonstrated, based on the results of their experiments on mice, that by lowering the level of (apo C-3), it is possible to significantly or even eliminate the harmful effect of fatty foods.
The experiments conducted by the researchers included dividing the mice into three groups. The first and second groups ate equally fatty foods. But the first group got a preparation to lower the level of (apo C-3), after the tenth week of the experiment, while the mice of the second group got from the first day of their inception. As for the third group, they continued to eat their usual food.
And it became clear to the researchers that the group of mice that were getting (apo C-3) since the first day of the experiment, did not have any metabolism disorder, as in the third group mice.
“With these experiments, we have shown that lowering the level of (apo C-3), regardless of consistently eating fatty foods, protects not only from harmful metabolic disorders of fats, but also from the Department of Molecular Medicine and Surgery at the Karolinska Institute. And it also removes them and restores insulin sensitivity. “
Of note, hepatocytes are the main protein producer (apo C-3). According to the researchers, the main apo C-3-lowering mechanisms used in the treatment include increased lipase activity and the liver’s absorption of fats by receptors. During a biochemical process (the ketogenic process), fatty acids are converted into ketones, which are then used to produce energy in brown adipose tissue, leading to fat consumption rather than storage.
Source: Novosti
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