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Australian scientists described the development of immunity within four months after infection with “Covid-19” disease and discovered, that the number of antibodies decreases rapidly in the first two months, but then slows down very much.
And the Nature Communications magazine indicates that the results obtained by the researchers show that the vaccination against “Covid-19” should stimulate the antibody response, more than the natural infection.
Researchers from the University of Melbourne, the Kirby Institute at the University of New South Wales and the University of Flinders studied the dynamics of changes over time in the response of the human immune system, particularly B and T cells, to the sudden rise of SARS-CoV-2.
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And the spike protein, it allows the emerging coronavirus to stick to human cells and multiply inside them. Therefore, it is important to understand how antibodies that neutralize the virus, upon infection again, interact with this protein.
As is well known, in this case, the functions of the immune system cells differ: B cells recognize foreign virus-antigen structures and have to produce antibodies. T cells support the development of the B cell response, regulate and direct immunity, and also carry out the task of eradicating the virus.
And it became clear to the researchers, that during their four-month follow-up of the patients, the number of B cells increased in all of them. “Our study and recent studies have shown that B cells continue to increase over time. This should be beneficial for protection, because in the event of recurrent infection, these cells become active,” said Dr. Jennifer Juneau, lead researcher from the Institute of Infection and Immunology at the University of Melbourne. Memory cells “again”.
The researchers point out that, until now, it is not known how much antibody needed to protect against recurring infection, whether it is a natural virus or vaccine, and how effective this protection will last. However, the results of the third phase trials of a number of vaccines showed that the immunity provided by the vaccines appears to be better than that which arises after natural infection.
“The information on the pioneering vaccines shows that they produce at least twice the number of antibodies produced by natural infection,” Juno said. “This is very encouraging, although we do not yet know how many antibodies we need for protection. We must also understand whether B cells can recognize.” , On the new SARS-CoV-2 mutations that are currently emerging, as well as protection from them. “
Source: Novosti
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