Globallookpress Galina Barbieri, Галина Барбиер / Global Look Press
An international group of scientists has determined the effect of green tea supplement on the facial makeup of children with Down syndrome, and it has been shown that the amount of dose determines these changes: moderate improvement in features and excess increase their deformation.
Scientific Reports indicates that Down syndrome is a genetic disease, as there are 46 chromosomes in each cell of the human body, while in the cells of people with Down syndrome it is 47, and this characteristic affects their physical and intellectual development. Because chromosomes contain genes that determine the functioning of all body systems, and when the extra chromosome is present, it changes the course of development of the human body. For example, one of the DYRK1A genes that the extra chromosome changes its activity controls the formation of brain structure. And the change of its activity determines the external features and behavior of people with Down syndrome.
Scientists were aware that epigallocatechin gallate (EGCG), a component of green tea, suppresses the activity of the DYRK1A gene. Previous studies revealed that this substance can improve thinking ability in young people with Down syndrome. Therefore, the international scientific group headed by scientists from Spain and Belgium decided to determine whether this substance was able to cause changes in the development of facial features in people with Down syndrome.
The researchers conducted the first tests on laboratory mice, where they added green tea extract to the drinking water of pregnant female mice (healthy and with Down syndrome), and monitored the development of the external appearance of their pups. And they discovered, that adding this substance in moderate quantities improved the features of 60% of young mice with Down syndrome and made it difficult to distinguish them from healthy ones. However, when adding large doses, it led to changes in the features of even the healthy mice.
Then, the researchers conducted a survey with the participation of people, in which they designed 3D models with the faces of 287 children, ages 0-18, who were sorted into three groups. The first is healthy, and the second has Down syndrome, but they do not receive green tea extract, and the third is infected and they receive green tea extract. And they used this extract themselves, without a prescription.
A comparison of all these aspects showed that the facial features of children aged 0-3 years who did not receive green tea extract differ from healthy children by 57%. As for the children who received the extract, the percentage of difference was 25%. And the researchers point out, that no improvement was observed from the consumption of green tea extract among adolescents, as the percentage of difference remained 50%.
Katholieke Universiteit Leuven.
From this, the researchers concluded, green tea extract only affects the early stages of life, when a child’s skull and face are actively growing.
The scientists point out that although these results can be considered encouraging, it is a preliminary study. Therefore, more experiments are needed, to obtain broader data to understand and determine the necessary dose. Clinical tests must also be conducted with the participation of a large number of volunteers, taking green tea extract under the supervision of doctors.
Source: Vesti. Ru