British authorities are ‘incredibly worried’ about the highly-infectious South African coronavirus mutation which top experts there fear could scupper the UK’s vaccine roll-out, the nation’s health secretary warned today.
Hancock warned the variant – which has already been spotted in the UK – posed a ‘very, very significant problem’.
The new variant, dubbed 501Y.V2 has become dominant in South Africa and was detected last week in the UK. It is thought to be more infectious and may even be capable of evading vaccines.
So far, the South African variant has not been reported in the US – but that doesn’t mean it hasn’t arrived.
The Centers for Disease Control and Prevention (CDC) aims to double the number of coronavirus samples it runs genome sequencing on from about 3,000 to about 6,500 a week.
Up until now, the US viral genome sequencing effort has been ‘a somewhat patchy system,’ admitted Dr Gregory Armstrong, director of the CDC’s Office of Advanced Molecular Detection at the agency’s National Center for Emerging and Zoonotic Infectious Diseases admitted in an interview with CNN.
The US failed to detect the UK variant – B117 – until last week, by which point it was already spreading within Colorado, instilling little confidence that American scientists would know if the South African ‘super-covid’ has arrived.
This map shows how the coronavirus variants have been tracked as they spread around the world. No cases of the South African variant have been detected in the US, but efforts to sequence the genomes of viral samples to find new mutations has been ‘patchwork’
Only some 57,000 coronavirus genome sequences have been submitted by the US to GISAID, an international database configured to help scientists around the world track how viruses change.
The UK has done much better, submitting about 141,000 sequences, despite seeing about 13 percent of the infections the US has.
British health authorities have a robust centralized set of labs working on viral genome sequencing.
In the US, that work is done by a chaotic array of private, county, state and federal labs, each of which have different processes and protocols.
The CDC SPHERES initiative is meant to coordinate these efforts.
The health agency has struggled to create efficient systems to bring together these same entities for testing and tracing and, now, for vaccination, raising questions about whether it will catch threatening new strains early.
The Health Secretary warned the variant — which has already been spotted in the UK — posed a ‘very, very significant problem’
Sir John Bell (pictured), regius professor of medicine at Oxford University, said the African strain is more concerning than the Kent one
Last week, the UK’s B117 coronavirus variant was found in three states: Colorado, California and Florida.
B117 is thought to be more contagious, but not more dangerous.
UK health officials are conducting studies to test vaccines against it.
The variant has driven up cases in the UK, prompting widespread lockdowns there and bans on British travelers enacted by most nations in the EU.
Hancock is much more concerned about the South African variant than he is about B117, however.
His comments came after one of the Government’s coronavirus advisers yesterday claimed there was a ‘big question mark’ over whether any of the current wave of jabs could protect against the mutant strain.
Sir John Bell, regius professor of medicine at Oxford University, argued the South African variant was more concerning than the Kent one because it has ‘pretty substantial changes in the structure of the protein’, meaning vaccines could fail to work.
Covid vaccines – including the Pfizer/BioNTech and Oxford University/AstraZeneca jabs currently being rolled out across Britain – work by training the body to spot the virus’s spike protein.
If the spike mutates so much that it becomes unrecognisable then it could render vaccines useless or make them less potent.
However, the current vaccines are believed to be effective against the Kent strain which is causing a massive spike in cases across the UK.
Q&A: Everything we know about the South African variant
Has the variant been found in the UK?
The variant was found in two people, one in London and another in the North West, who came into contact with separate people returning from South Africa.
The fact that they were detected through random routine sampling which picks out only around one in 10 tests carried out in the UK – and that they are thought to have been infected by separate travellers – suggests there are many more cases of the variant already in Britain.
Health Secretary Matt Hancock said it was ‘highly concerning’ and the variant was ‘yet more transmissible’ than the original strain the UK has been battling.
Where has the new strain come from?
The new variant emerged after the first wave of coronavirus at Nelson Mandela Bay, in South Africa’s Eastern Cape Province, and rapidly became the dominant strain in the area.
South Africa picked up the strain using genomic sequencing.
It was discovered in mid-December and is believed to have caused infections to soar from under 3,000 per day at the beginning of the month to over 9,000 by the end.
Where else has the variant been found?
Confirmed cases have been announced in France, Japan and Britain.
It is likely to be circulating in many more countries but only a select few nations have the genomic sequencing ability to be able to spot it when it’s present in low numbers.
What has been done to tackle it?
Both of the people in the UK who had the new strain of the virus were quarantined, along with their close contacts.
Public Health England researchers are currently investigating the variant at their research laboratory at Porton Down in Wiltshire.
All flights to and from South Africa have been banned.
What does it mean for the fight against the virus?
One mutation in the new strain, called N501Y, is thought to help the virus become more infectious – and spread more easily between people.
That means measures such as social distancing, wearing masks and avoiding unnecessary contacts have become more important.
What about the vaccine?
Dr Susan Hopkins, from Public Health England, told the Downing Street press conference there is no evidence the new strain may stop coronavirus vaccines from working.
Scientists will test the blood of those who have been vaccinated against coronavirus, or have recovered from it, to ensure they can fight off the new strain.
But Sir John Bell, regius professor of medicine at Oxford University, argued the strain was more concerning than the Kent one. He said it has ‘pretty substantial changes in the structure of the protein’, meaning vaccines could fail to work.
The Covid vaccine protects against the disease by teaching the immune system how to fight off the pathogen.
It creates antibodies – disease-fighting proteins made and stored to fight off invaders in the future by latching onto their spike proteins.
But if they are unable to recognisz proteins because they have mutated, it means the body may struggle to attack a virus the second time and lead to a second infection.
Viruses are expected to morph over time, but the South African variant has more mutations than most.
Eight of these are found on the spike protein – the target of vaccines.
Some are shared with the Kent variant, but others are unique.
One, called E484K, is particularly alarming, Dr Richard Lessells, an infectious-disease specialist at the KwaZulu-Natal Research Innovation and Sequencing Platform, told the Wall Street Journal.
When he and his team tested antibodies from donated plasma or lab made ones against that mutated bit of the virus variant, the immune cells were less effective.
‘The mutation is probably changing the formation of the protein so that the antibodies can’t get a good grip on it,’ he told the outlet.
However, vaccines trigger a whole host of immune responses – not just antibody production – so he remains hopeful that they will work against the variant.
As of yet, here is no concrete evidence to suggest the South African strain is more deadly or causes more severe illness than regular Covid.
But South Africa’s health minister, Dr Zweli Mkhize, has warned there has been ‘anecdotal evidence’ of a ‘larger proportion of younger patients with no co-morbidities presenting with critical illness’.
Discussing the threat posed by the South African variant, Mr Hancock told BBC Radio 4’s Today programme: ‘I’m incredibly worried about the South African variant
‘And that’s why we took the action that we did to restrict all flights from South Africa and movement from South Africa and, in fact, to insist that anybody who’d been to South Africa to isolate.
‘This is a very, very significant problem, in fact I spoke to my South African opposite number over Christmas and one of the reasons they know they have a problem is because, like us, they have an excellent genomic-scientific [programme] to be able to study the details of the virus and it is even more of a problem than the UK new variant.’
It comes after Sir John told Times Radio yesterday: ‘The mutations associated with the South African form are really pretty substantial changes in the structure of the protein.
‘My gut feeling is the vaccine will be still effective against the Kent strain
‘I don’t know about the South African strain – there’s a big question mark about that.’
Vaccine makers – including experts at Oxford – have said they are already looking at ways to tweak their jabs to protect people from new variants.
Professor Sarah Gilbert, one of the leading scientists behind the Oxford/AstraZeneca vaccine, told the BBC today: ‘We are looking at how well [the vaccines] work on these new variants and others that will come in the future.
‘And we’re also thinking about what we’ll need to do if it ever becomes necessary to replace the version of the vaccine we’re using now with a new one.
‘We don’t think we’re at that point yet, there’s no reason to suppose we need to make a switch now but it is possible that in the future we need to make a tweak, a change, to the vaccine.
‘So, with my team, I’m still working on how we make that change really quickly if we ever need to.’
Asked how quickly that change could come if needed, Professor Gilbert added: ‘We don’t expect to have to make a switch in the near future. But we’re thinking that this vaccine is going to be used over a period of many years probably.
‘As with flu vaccines we have a new version every year, which takes into account the changes in flu viruses circulating. Something similar is probably going to have to happen with the coronavirus vaccines.
‘I don’t think it’s necessarily going to be a very rapid switch that we have to make. But what we might be looking at is when we’re coming round to planning vaccinations for next autumn, thinking about another wave at end of 2021, which is a theoretical possibility, we will be considering whether to continue with the same version [of the vaccine] or a different version.’
Britain first sounded the alarm about the variant VUI-202012/01 in December after an explosion of cases were linked to the strain.
Top virologists in the US since admitted the strain – which was first seen in a patient in September – could have emerged there and went undetected because America’s genomics scheme is ‘sporadic’.
Australia, Italy, Iceland, Spain and the Netherlands are among the countries who have since reported cases of the UK variant.
Other Covid strains with near-identical genetic make up have also been reported in South Africa – with strain 501.V2 – and Nigeria – who detected strain P681H.
South Africa detected 501.V2, which is feared to be more extreme than the UK’s VUI-202012/01.
Several countries have banned travellers from South Africa to try and contain the spread of the new strain, including the UK, Germany, Saudi Arabia and Turkey.
But the variant has already been detected in two locations in Britain in contacts of people who had recently visited the African nation.
On Christmas Eve, another new variant called P681H was detected in Nigeria.
Scientists say it is different to the other two but they do not currently believe the Nigerian strain is more infectious than previous strains.
Concerns about vaccine ineffectiveness comes ahead of a major rollout of the Oxford coronavirus vaccine on Monday.
In the biggest UK mass vaccination drive ever, half a million doses will be made available for vulnerable people this week with ‘tens of millions’ promised by April.
He said: ‘This is a pivotal moment in our fight against this awful virus and I hope it provides renewed hope to everybody that the end of this pandemic is in sight.’
WHERE ARE THE UK’S MASS VACCINATION CENTRES
The UK has approved 40 large-scale vaccination centres. Here is a list of those whose locations have been finalised:
1. Edinburgh International Conference Centre
2. Newcastle, Centre for Life Science Park
3. Southern Trust – South Lake Leisure Centre, Craigavon
4. Northern Trust – Seven Towers Leisure Centre, Ballymena
5. Western Trust – Foyle Arena, Londonderry
6. Omagh Leisure Complex, Omagh
7. Lakeside Leisure Forum, Enniskillen
8. St Helens, Totally Wicked Stadium
9. Manchester Tennis & Football Centre
10. Derby Arena
11. Birmingham – Millennium Point and Black Country Living Museum, Dudley
12. Leicester Racecourse
13. Stevenage, Robertson House Conference Centre
14. London Nightingale Hospital at the ExCel Centre
15. Epsom Racecourse, Surrey 16. Bristol, Ashton Gate football stadium
17. Exeter, Sandy Park rugby stadium
Elderly and infirm people in Oxford, London, Brighton, Morecambe in Lancashire and Nuneaton in Warwickshire are due to be first to receive the jab.
A total of 530,000 doses will be made available at 540 GP vaccination sites and 101 hospitals this week.
The NHS has ordered 100million doses which it is hoped will free the country from Covid-19.
An army of current and former NHS staff have applied to give the jabs, with tens of thousands having already completed their training.
The vaccine is the second to be made available after a million Britons received the Pfizer-BioNTech jab. The Oxford vaccine is easier to use, as it does not require storage at extremely low temperatures.
Yesterday Boris Johnson hailed the UK’s vaccine progress. He told the BBC’s Andrew Marr Show: ‘The UK remains the first country to get a stage three approved vaccine into people’s arms. Vaccinating a million people, as we have already, we exceed the whole of the rest of Europe put together.’
A total of 524,439 people already vaccinated are aged 80 and over – around one in five of that age group.
Supermarket giant Tesco and chemist Boots have offered to help with the rollout of the vaccines.
Boots is opening three Covid-19 vaccination sites in Halifax, Huddersfield and Gloucester while Tesco will help distribute the Oxford vaccine.
The Ministry of Defence has deployed 10 military planners to assist the Government’s Vaccine Taskforce, with over 150 personnel working across the UK.
Rollout of the Pfizer/BioNTech jab began almost a month ago.
But both jabs require second doses which will now take place within 12 weeks rather than 21 days as initially planned to ‘protect the greatest number of people in the shortest time’, health chiefs said.
The Government was yesterday forced to deny claims there was a ‘postcode lottery’ as GPs in some areas have not agreed to deliver the vaccine.