Bath flanker Sam Underhill has withdrawn from England’s Six Nations squad because of a hip injury.
Wasps flanker Jack Willis has replaced Underhill in the squad.
Underhill, 24, is expected to miss the whole championship, although his exact recovery time has yet to be determined.
England are already without Mako Vunipola and Joe Launchbury, while prop Joe Marler is unavailable for personal reasons and Kyle Sinckler is suspended for the opener against Scotland.
The Calcutta Cup match is at Twickenham on Saturday, 6 February (16:45 GMT).
Exeter loosehead prop Alec Hepburn, Northampton flanker Lewis Ludlam and their lock David Ribbans have all been added to the shadow squad.