GlycoMimetics (GLYC) is a clinical-stage drug developer aiming to generate what’s known as glycobiology-based therapies for cancers.
This 1 has a catch, even so. It really is a compact biotech name. But inspite of an roughly $150 million current market capitalization, options from this fairness have good liquidity and are quite worthwhile. The firm also has a large amount of probable.
My principal fear: That Glyco could get purchased for a important high quality in which case I may go away a lot of money on the desk. Say la vie.
The firm has a single medical asset, uproleselan, for acute myeloid leukemia and another just one that is clinically cleared but wanting for a development associate. Uproleselan has been granted “rapidly monitor” designation from the Foodstuff and Drug Administration, breakthrough therapy designations from regulatory authorities in the U.S. and China, and “orphan” designations from the Fda and the European Medications Agency.
This candidate developed encouraging info in early clinical trials. Based on these success, uproleselan has been entered in numerous late-stage trials, such as a double-blind, placebo-managed stage 3 study to assess it in the treatment method of 388 relapsed acute myeloid leukemia sufferers. The clients are randomized 1:1 to acquire either an introductory round of uproleselan and chemotherapy, adopted by 3 further cycles of uproleselan and chemo — or an introductory round of placebo and chemo followed by 3 added cycles of placebo and chemo.
The returns to day have been most likely groundbreaking. The overall survival function cause was originally predicted at about 22 months — great thinking of that Astellas’ (ALPMF) Xospata and Jazz Pharmaceuticals’ (JAZZ) Vyxeos have been permitted with median over survival rates of 9.3 months and 9.5 months, which have been activated at 17.8 months and 20.5 months, respectively. On the other hand, in an update offered in November 2022, administration indicated that median observe-up is now predicted to be activated at 34.5 months, delivering important improvement more than the other two therapies.
In actuality, the news was so encouraging that the Food and drug administration elected to carry out a utility analysis in which an independent knowledge monitoring committee will critique information at 80% of prepared situations by the stop of the first quarter of 2023 to decide if the research should continue to 100% gatherings activated (in the vicinity of 12 months-conclude 2023) or unblind the information early thanks to compelling proof of profit. An unblinding would result in an quick new drug software filling by the enterprise. This disclosure has brought on a substantial and justified rally in the stock above the earlier couple months.
Additionally, GlycoMimetics’ compound is staying assessed as a front-line therapy in a 262-affected person Phase 2/3 examine in which recently identified men and women will be randomized to receive possibly an introductory spherical of uproleselan and chemo adopted by 3 rounds of uproleselan and chemo -OR- an introductory round of chemo adopted by three rounds of chemo. The Period 2 part was completely enrolled in December 2021 with an interim readout envisioned sometime in 2023.
The business ended the 3rd quarter with just above $50 million truly worth of dollars and marketable securities on its stability sheet. This should fund it by way of 2023, but I would not be amazed if the organization raises supplemental funds in the future quarter or two. If I were the CFO, I would in all probability execute that increase, if the Fda unblinds the research which someday this quarter.
Accumulate a posture in GLYC utilizing a covered contact strategy. Deciding on the June $2.50 simply call strikes, you will style a included contact purchase with a internet debit in the $1.60 to $1.70 a share assortment (web stock cost – possibility premium). This tactic offers draw back protection of approximately 35% and 50% of upside likely even if this stock does practically nothing in excess of the possibility period.
(You should observe that thanks to aspects which include low industry capitalization and/or inadequate general public float, we look at this inventory to be a little-cap stock. You really should be conscious that these stocks are subject to a lot more chance than shares of much larger companies, such as larger volatility, lower liquidity and much less publicly readily available facts, and that postings these as this just one can have an outcome on their stock selling prices.)
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