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Alzheimer’s drug stirs hope for patients, worry for doctors

by souhaib
June 28, 2021
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What is Alzheimer’s disease?

Alzheimer’s Association Chief Scientific Officer Dr. Maria Carrillo explains what Alzheimer’s disease is and how much it costs the U.S. health care system.

In the weeks since a new Alzheimer’s drug was approved, hopeful patients have bombarded Dr. Alireza Atri with calls and emails about a treatment that has sparked both excitement and skepticism.

They want to know if the drug might be right for them. Like many physicians, Atri has no easy answers.

“It’s not a simple yes or no,” said the neurologist at the Banner Sun Health Research Institute in Arizona.

It probably won’t be for a while. Doctors across the country are still trying to figure out who should receive the drug called Aduhelm, which, at best, slows the fatal disease marginally. Other drugs for Alzheimer’s disease only temporarily ease symptoms like memory problems, insomnia and depression.

While some clinics have already started giving the drug, many providers say it will take weeks or months before they are ready. Insurers — including the biggest bill payer for this drug, Medicare — still need to determine which patients to cover for a treatment that could cost more than $50,000 a year. And doctors worry that emotions will affect decisions by patients and families in seeking the drug.

“People are desperate. It’s a really horrible disease,” said Stanford University’s Dr. Michael Greicius.

Karl Newkirk hopes to start taking Aduhelm if his doctor gives the OK because he doesn’t see any other treatments worth trying.

“It looks like the only star in the sky,” said the 80-year-old Sarasota, Florida, resident, who has early-stage Alzheimer’s.

Newkirk’s doctor confirms he’s a good candidate for the drug. While the retired technology consultant is still fit enough to ride roller coasters with his grandchildren at nearby Busch Gardens, he struggles with short-term memory loss. He wants to try Aduhelm, even though he’s aware of the drug’s limits.

Michele Hall, 54, of Bradenton, Florida, also is eager to discuss the drug at her next appointment with an Alzheimer’s specialist.

A former government attorney, Hall had to quit her job after struggling with once-simple tasks like spelling, public speaking and remembering deadlines. She was diagnosed with early Alzheimer’s last November by doctors at the Mayo Clinic.

Hall calls Aduhelm “the first tiny glimmer of hope” that she’ll get more quality time with her husband and their three adult children.

BIOGEN’S STOCK SOARS AS ALZHEIMER’S DRUG COSTS REVEALED

“When you get that diagnosis, you really wake up every morning and go ‘Here I am, it’s ticking away and I’m just waiting,’” she said. “Well, now you have something to look forward to.”

Biogen’s Aduhelm is the first Alzheimer’s medication in nearly 20 years. Its Food and Drug Administration approval earlier this month triggered a swift backlash from many experts, including the agency’s own outside advisers who had warned that its supposed benefit relied on flimsy data. Three resigned over the FDA’s decision.

Aduhelm does not reverse mental decline. It only slowed it in one study that was marred by hard-to-interpret results. The data were so murky that the FDA ultimately granted the drug conditional approval based on a different measure: it’s ability to get rid of harmful clumps of plaque in the brains of patients with early forms of the disease.

The FDA approval isn’t limited to those early patients. Anyone with Alzheimer’s — at least theoretically — could get prescribed the drug. But advocacy groups like the Alzheimer’s Association and many doctors say the focus should be patients with an early diagnosis, like those helped in the study.

“I don’t want to see people pull their mothers from nursing homes to get this treatment,” said Dr. Babak Tousi, a Cleveland Clinic geriatrician who consulted with Biogen and helped run one of the testing sites for Aduhelm.

This image provided by Biogen on Monday, June 7, 2021 shows a vial and packaging for the drug Aduhelm. On Monday, June 7, 2021, the Food and Drug Administration approved Aduhelm, the first new medication for Alzheimer’s disease in nearly 20 years, disregarding warnings from independent advisers that the much-debated treatment hasn’t been shown to help slow the brain-destroying disease. (Biogen via AP)

This image provided by Biogen on Monday, June 7, 2021 shows a vial and packaging for the drug Aduhelm. On Monday, June 7, 2021, the Food and Drug Administration approved Aduhelm, the first new medication for Alzheimer’s disease in nearly 20 years, disregarding warnings from independent advisers that the much-debated treatment hasn’t been shown to help slow the brain-destroying disease. (Biogen via AP)



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