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A new study published in Science Translational Medicine In pregnant women who tested positive for coronavirus, the male placenta showed an increase in immune activity compared to the female placenta, as it was found that mothers with coronavirus who had male fetuses make lower levels of antibodies against the virus compared to mothers who had female fetuses, and they also transferred fewer From antibodies to a male fetus, this indicates that males may be more susceptible to infection with the Corona virus in infancy, and explains that the gender of the fetus can affect the mother’s immune response to the virus.
baby gender
According to a Harvard University statement on its official website, significantly elevated levels of some genes and proteins associated with increased immune activation may help protect male fetuses from infection with the Corona virus in the womb, but the resulting inflammation may pose risks to the fetus and child, according to Andrea Idlo, senior The authors are study specialist and maternal-fetal medicine at Harvard-affiliated Massachusetts General Hospital (MGH).
Moreover, pregnant women infected with the Corona virus transferred much less immunity from the virus to male fetuses than to female fetuses, which may affect the risk of infection of the infant with the Corona virus. her baby“.
This is the first study to investigate gender differences in the transmission of maternal antibodies from MERS-CoV infection to her fetus, and the first to examine gender differences in the placenta’s response to maternal infection..
Epidemiological studies have shown that adult males, children, and infants have a higher prevalence of corona infection and develop more severe disease than females, and male fetuses and infants are also more susceptible to a range of prenatal and perinatal exposures compared to female children, so Idlow and his team sought to examine the placenta and blood Maternal and umbilical cord blood pregnancies affected by maternal SARS infection.
The study included 68 pregnant women, 38 of whom contracted coronavirus during the third trimester of pregnancy before the coronavirus vaccine was developed. The remaining 30 were healthy pregnant women who tested negative for COVID-19 during pregnancy. In both groups, half of the fetuses were male and the other half were female..
In a new finding, the study showed that, compared to female fetuses, the placentas of male fetuses carried by women with COVID-19 had significantly higher expression of interferon-inducible genes. (ISGs) , which plays a key role in protecting fetuses from viral invaders in the womb.
“Although our study did not specifically assess these risks, it does increase the importance of following these children and looking at male and female fetuses differently,” the researchers emphasized.“.
In a second important discovery, the research team showed that mothers with corona who have male fetuses make lower levels of antibodies against the virus compared to mothers who have female fetuses. They also transfer fewer antibodies to a male fetus, which indicates that males may be more susceptible to infection with the Corona virus in infancy, and explains that the gender of the fetus can affect the mother’s immune response to the virus.
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