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Nipah virus (NiV) It is a highly contagious virus that causes severe and sporadic infections, which has reappeared strongly in India, and a vaccine similar to Cocoshield for Corona was found successful in monkey experiments against the Nipah virus, according to an international team of researchers.
According to a report by the site time now news The Nipah virus claimed the life of a 12-year-old boy in the Indian state of Kerala, while all high-risk contacts of the deceased came negative, neighboring states were placed on high alert for the disease, as the outbreak of the virus in the state in 2018 killed 17 of the dead. Of the 18 confirmed cases of the virus, no vaccines against Nipah have been approved.
Researchers from Oxford University and the US National Institutes of Health investigated the efficacy of ChAdOx1 NiV in eight African green monkeys and published the results on a bioRxiv server before printing. .
While one group of four monkeys was given either two or one doses of ChadOx1NiV, the other group was injected with a placebo protein (ChAdOx1 GFP), and then the eight were infected with the true Nipah virus, some given intranasally and others orally, and a humoral response was detected. and robust cellularity starting 14 days after the initial vaccination when control animals were artificially infected with Nipah virus, and they showed a variety of signs.
In contrast, the vaccinated animals did not show any signs of disease, and we were unable to detect the infectious virus in all tissues except for one smear.
Sarah C Gilbert of the University of Oxford said: ‘Limited antibodies cannot be detected against a fusion protein or a nucleoprotein IgG 42 days after infection with Nipah virus, indicating that vaccination induced a very strong protective immune response that prevented widespread viral replication..
The researchers previously showed that a single dose of ChAdOx1 NiV provides complete protection for hamsters, and the team also found limited evidence of virus replication in vaccinated animals, and all but one of the swabs were negative for the infectious virus and no virus was found in tissues taken from vaccinated animals. These data suggest that the vaccine may provide protective immunity.
